Showing posts with label neurology. Show all posts
Showing posts with label neurology. Show all posts

Wednesday, January 3, 2024

The Base of The Human Brain Illustration From De Humani Corporis Fabrica Libri Septum (1543)

 


Andreas Vesalius wrote De Humani Corporis Fabrica Libri Septum, which revolutionized medicine. The seven volume work was the most detailed text on human anatomy. Vesalius was able to get bodies for dissection and this enabled him to give descriptions of the human body. Many of his discoveries disproved Claudius Galen's medical assertions. Galen's concepts had been dominant since the Roman Empire. Galen did not have the advantage of cadavers for dissection. The impressive element of Vesalius' work is the detailed illustrations of organs and their systems. The image of the human brain is the most incredible. The illustration shows the base of the brain. What can be seen are the cerebellum, olfactory bulbs, and optic nerves. The left and right hemispheres show both fissures and convolutions. The drawing is precise to a contemporary medical text. What was missing from Humani Corpis Fabrica was the depiction of neurons. The reason was a limitation of technology. Andreas Vesalius did not have access to a microscope. Without such tools certain parts of the human body could not be detected. Vesalius did not fully comprehend the brain's physiology. The understanding  of neurotransmitters and electrical impulses through the brain cells would come centuries later. Surgeons and doctors probably had a suspicion that the brain was responsible for the senses. The challenge was proving transduction to be true. The human brain is the most complex organ of the body. It controls movement, consciousness, thought, and involuntary biological function. There is more to uncover about this intricate organ. Vesalius put emphasis on an observational methods. The teaching of medicine and surgery changed to a more empirical approach.  

Wednesday, January 11, 2023

The Subarachnoidal Lymphatic-like Membrane Has Been Discovered

 


An incredible discovery has been made in neuroanatomy. A new structure known as the subarachnoidal lymphatic-like membrane was detected. The previously unknown anatomical structure was discovered through neuro-imagining and techniques developed by microbiology. The structures function most likely acts as a protective barrier. The area can be a place in which immune cells monitor the brain from infections and inflammation. The discovery was made through research by the University of Rochester and University of Copenhagen. The new information reveals much about the connection between cerebrospinal fluid and immune system response. The brain has a method of waste disposal and protection. The common understanding was that the meningeal layer had only three layers. Those layers included the dura, arachnoid, and pia layers. The new layer is located between the arachnoid and pia layers.   The newly discovered membrane is similar to mesothelium. These membranes are designed to protect organs in the body. The subarachnoidal lymphatic-like membrane is a much thinner membrane, but still very selective about what molecules pass through to get access to cerebrospinal fluid. The discovery can be utilized to have a greater understanding of diseases of the brain. Abnormalities in the membrane could have a role in multiple sclerosis, dementia, and severe central nervous system infections. The clue given was that a larger amount of immune cell gather in the SLYM during inflammation. This also happens during aging. The brain does change with age. Knowing more about the brain can ensure the best methods of maintaining cognitive health. More information can also aid in treating traumatic brain injuries.  The subarachnoidal lymphatic-like membrane contains its own central nervous system immune cells. The discovery of this anatomical structure demonstrates there is much more to learn about immune system response and the nervous system.